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International researchers who study islets of Langerhans met for a conference in Malmö in June. Studies of insulin-producing cells help us understand disease mechanisms in diabetes. Lund University Diabetes Centre and the strategic research area EXODIAB hosted the event. Lund University Diabetes Centre (LUDC) and the strategic research are EXODIAB (Excellence of Diabetes Research in Sweden) hosted

https://www.ludc.lu.se/article/international-islet-cell-researchers-met-conference-malmo - 2025-11-21

Congratulations to Charlotte Ling who, together with Katarina Fagher and Alice Maguolo, has been awarded a grant of five million Danish kroner by the Novo Nordisk Foundation. The funding will support clinical research in precision medicine, focusing on epigenetic analysis of blood samples from 13,000 individuals. Charlotte Ling, a professor in diabetes research with a particular focus on epigeneti

https://www.ludc.lu.se/article/charlotte-ling-receives-major-grant-clinical-diabetes-research - 2025-11-21

An international research team led from Lund University, has identified epigenetic biomarkers that can predict which people with type 2 diabetes are at risk of cardiovascular disease. The study is now published in Cell Reports Medicine. People with type 2 diabetes are up to four times more likely to have heart attacks, strokes, anginas and other coronary heart diseases than healthy people. Therefo

https://www.ludc.lu.se/article/biomarkers-reveal-risk-cardiovascular-disease-type-2-diabetes - 2025-11-21

Inflammation researcher Ben King studies the function of two different proteins in connection with diabetes. In the future, such knowledge may be important for the development of new treatments for people with diabetes. Ben King is this year’s recipient of the Medeon Award for his innovative research. “I was very surprised and feel very honored to receive the award. In my role, I do a lot of exper

https://www.ludc.lu.se/article/award-protein-research-may-lead-new-treatments-diabetes - 2025-11-21

We would like to congratulate six researchers at Lund University Diabetes Centre, who have been awarded research grants within medicine and health by the Swedish Research Council (VR). The six researchers are affiliated with Excellence of Diabetes Research in Sweden (EXODIAB), which is a strategic research area within diabetes at Lund University.Helena Elding Larsson, professor of autoimmune disea

https://www.ludc.lu.se/article/six-ludc-researchers-receive-medicine-and-health-grants-vr - 2025-11-21

An international team of researchers has investigated whether oral insulin can prevent early signs of type 1 diabetes and clinical diagnosis in children with an increased risk of developing the disease. Although treatment with oral insulin could not prevent development of diabetes-related autoantibodies, oral insulin delayed the rate of disease progression in children who developed such autoantibo

https://www.ludc.lu.se/article/oral-insulin-delayed-onset-type-1-diabetes-some-children-increased-risk-disease - 2025-11-21

Social and economic factors have led to a dramatic rise in type 2 diabetes and obesity around the world. In a review in Science, Mark McCarthy, professor at the University of Oxford, UK, and Paul Franks, professor at Lund University, Sweden, examine the knowledge of the actual causes and the interplay between genetics and lifestyle factors. By studying how our genes express themselves in response

https://www.ludc.lu.se/article/review-type-2-diabetes-and-obesity-what-do-we-really-know - 2025-11-21

Diabetes researchers at Lund University have previously shown that people with diabetes can be stratified into five subgroups with differing disease progression. A new study by the same researchers provides increased evidence for the clinical relevance of the classification system. The researchers also present new findings of significant differences between subgroups in the development of complica

https://www.ludc.lu.se/article/new-research-classification-diabetes-identifies-high-risk-group - 2025-11-21

How can a tiny genetic change alter the body´s sugar balance? At Lund University, researchers have used stem cells to create two versions of the same cell – one carrying the genetic variant and one without – to see how melatonin affects insulin-producing cells and contributes to development of type 2 diabetes. Study summarySkin cells from a person carrying a risk gene for type 2 diabetes were “rep

https://www.ludc.lu.se/article/stem-cell-technology-reveals-new-insights-melatonin-and-diabetes - 2025-11-21

Lund University Diabetes Centre has entered into a collaboration with the Regeneron Genetics Center LLC (RGC) and the University of Helsinki involving exome-sequencing and whole genome array genotyping of greater than 9,000 individuals. The collaboration will involve the largest sequencing study in diabetes families to date and aims to help generate knowledge about how to predict diabetes, causes

https://www.ludc.lu.se/article/lund-initiates-genetic-sequencing-study-diabetes-families-provide-new-insights-what-causes-disease - 2025-11-21

Research from Lund University in Sweden can explain why type 2 diabetes is inherited to a greater extent from an individual’s mother. The heredity of a previously known risk gene, THADA, has proven to be dominant if it comes from the mother, whereas it has little or no effect on the child’s risk of disease if it originates from the father.
“Our research contributes to increased knowledge about the

https://www.ludc.lu.se/article/thada-new-findings-role-mother-type-2-diabetes - 2025-11-21

A new experimental and clinical study from Lund University in Sweden shows that the sleep hormone melatonin impairs insulin secretion in people with a common gene variant.

“This could explain why the risk of type 2 diabetes is greater among, for instance, overnight workers or people with sleeping disorders”, says Professor Hindrik Mulder who is responsible for the study. Melatonin is a naturally

https://www.ludc.lu.se/article/new-findings-explain-connection-between-melatonin-and-type-2-diabetes - 2025-11-21

One in three people with diabetes will face some form of renal impairment in the course of their lives. Studies conducted by researchers at the Lund University Diabetes Centre may lead to the development of an entirely new principle for treating type 2 diabetes and preventing kidney damage in the future. Previous analyses have not been able to identify genetic causes as to why some people have a h

https://www.ludc.lu.se/article/new-findings-can-lead-new-principle-treating-diabetic-kidney-damage - 2025-11-21

One in three people with diabetes will face some form of renal impairment in the course of their lives. Studies conducted by researchers at the Lund University Diabetes Centre may lead to the development of an entirely new principle for treating type 2 diabetes and preventing kidney damage in the future. Previous analyses have not been able to identify genetic causes as to why some people have a h

https://www.ludc.lu.se/article/new-findings-can-lead-new-principle-treating-diabetic-kidney-damage-0 - 2025-11-21

The European Research Council makes a large investment in diabetes research. A project led by Professor Paul Franks at Lund University Diabetes Centre is to develop methods that can be used in the design of preventive treatment for type 2 diabetes and cardiovascular disease. - Through this project we will use functional genomics and epidemiology to identify novel molecular mechanisms that underlie

https://www.ludc.lu.se/article/focus-personalized-treatment-type-2-diabetes-and-cardiovascular-disease - 2025-11-21

Social and economic factors have led to a dramatic rise in type 2 diabetes and obesity around the world. In a review in Science, Mark McCarthy, professor at the University of Oxford, UK, and Paul Franks, professor at Lund University, Sweden, examine the knowledge of the actual causes and the interplay between genetics and lifestyle factors. By studying how our genes express themselves in response

https://www.ludc.lu.se/article/type-2-diabetes-and-obesity-what-do-we-really-know - 2025-11-21

1) We found 15 national/regional registries of congenital heart disease worldwide. 2) Registry coverage ranged from 25 to 100% of all eligible cases. 3) The best registries contain demographic, clinical, physical, and laboratory data. 4) Regular verification is essential for quality data and valid statistical findings. Read the paper at https://www.sciencedirect.com/science/article/pii/S0167527321

https://www.lupop.lu.se/article/national-and-regional-registries-congenital-heart-diseases-strengths-weaknesses-and-opportunities - 2025-11-21

Quantitative bias analyses allow researchers to adjust for uncontrolled confounding, given specification of certain bias parameters. When researchers are concerned about unknown confounders, plausible values for these bias parameters will be difficult to specify. Read the paper at https://journals.lww.com/epidem/Fulltext/2021/09000/The_Importance_of_M…

https://www.lupop.lu.se/article/importance-making-assumptions-bias-analysis - 2025-11-21

The benefits of using data from national registers as endpoints in epidemiological studies include faster, less resource-intensive access to nationwide data and considerably lower loss to follow-up, compared to manual data collection in a limited geographical area. Read the paper at https://www.dovepress.com/validating-acute-myocardial-infarction-diagno…

https://www.lupop.lu.se/article/validating-acute-myocardial-infarction-diagnoses-national-health-registers-use-endpoint-research - 2025-11-21

The integrative data approach is an effective way to conduct cancer research assessing multilevel factors on cancer outcomes among small populations. Read the paper at https://cebp.aacrjournals.org/content/30/8/1506.long

https://www.lupop.lu.se/article/integrating-electronic-health-record-cancer-registry-and-geospatial-data-study-lung-cancer-asian - 2025-11-21